Endocrine Abstracts

Background: The expression and/or co-expression of somatostatin (sstr1–5) and dopamine (DR) receptors in neuroendocrine tumors (NETS) is of clinical interest as their expression implies that NETS could be treated with combined targeted therapy. In addition, the expression of sstrs permits tumour visualization with radiolabelled sst analogs (111In-DTPA-OctreoScan).Methods: We analyzed preoperative Octreoscans findings (also graded for the ...

Objective: The prevalence of metastatic bone disease in patients with neuroendocrine tumours (NETs) and their response to first line treatment with biphosphonates.Methods: We studied 271 patients (141 females) with NETs: 54 gastric, nine duodenal, 102 pancreatic, 29 small intestine, 29 appendix, 14 colon, 15 lung, one thymic, 20 unknown primary and ten elsewhere. Since September 2012 all patients with NETs and bone metastases were recruited to receive 4 ...

Objective: Conflicting findings have been published regarding the pressure wave reflection and the arterial stiffness in young women with PCOS as opposed to the overt ab initio presence of endothelial dysfunction compared with controls which can be reversed six months after metformin administration. The aim of this study was to investigate arterial stiffness and wave reflections in young women with polycystic ovary syndrome (PCOS) with respects to the different weight...

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...

Introduction: Thyroid autoimmunity and diabetes mellitus type 2 (DM2) are the commonest endocrine disorders in the general population. The aim of the study was to investigate whether there is an association between thyroid autoimmunity and β-cell secretion in patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).Methods/design: 501 patients (381 females) 46.5±14.2 years with IFG and/or IGT and autoimmune thyroidit...

Introduction: Neuroendocrine neoplasms (NENs) are rare and heterogeneous neoplasms with variable biological behaviour but generally slow progression.Methods/design: 355 patients with NENs registered in our data-base have been studied (166 females, mean age: 52 years; range: 11–88), during the period 2004–2014. TNM system has been used for staging and proliferation index Ki-67 for grading.Results: Out of 355 patients, 35 (...

Introduction: ACTH-secreting pituitary carcinomas are rare neoplasms but there are not factors till now to predict their aggressive evolution nor a standard practice to their management.Case report: We report a 43-year-old female patient presented in 1990 with Cushing’s syndrome due to ACTH-secreting pituitary microadenoma who had been submitted on trans-sphenoidal surgery with cure as defined by post-operative cortisol serum levels <50 nmol/l. ...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a genetic disorder involving mainly parathyroid tumours, pancreatic neuroendocrine neoplasms (pNENs) and pituitary tumours. In the present study we have registered demographic, clinical, imaging, pathological characteristics, therapeutic options, response to treatment and overall outcome of patients with MEN1.Methods/design: 35 patients with MEN1 registered in our data base have been studied (14...